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Home > Featured Articles > Foot-and-mouth disease virus capsid protein VP1 interacts with host Ribosomal protein SA to maintain activation of the MAPK signal pathway and promote virus replication > Foot-and-mouth disease virus capsid protein VP1 interacts with host Ribosomal protein SA to maintain activation of the MAPK signal pathway and promote virus replication

Foot-and-mouth disease virus capsid protein VP1 interacts with host Ribosomal protein SA to maintain activation of the MAPK signal pathway and promote virus replication [1]

Foot-and-mouth disease virus (FMDV) is the causative agent of foot-and-mouth disease, a highly contagious, economically important viral disease. [2] The structural protein VP1 plays significant roles during FMDV infection. Here, we identified that VP1 interacted with host ribosomal protein SA (RPSA). RPSA is a viral receptor for dengue virus and classical swine fever virus infections. However, the incubation of susceptible cells using the anti-RPSA antibodies did not block the infection of FMDV.

Original Source [3]

Publication Date: 
01/02/2020
Lisa J. Henderson [4], Lauren B. Reoma [5], Joseph A. Kovacs & et al [6]
Journal of Virology [7]
94
3
1-15
Tags:
Foot and Mouth Disease (HFMD) [8], Viral Diseases [9], Livestock [10], Animal Diseases [11]

Technology Partners: MimirTech

Source URL: http://re.indiaenvironmentportal.org.in/feature-article/foot-and-mouth-disease-virus-capsid-protein-vp1-interacts-host-ribosomal-protein-sa

Links:
[1] http://re.indiaenvironmentportal.org.in/feature-article/foot-and-mouth-disease-virus-capsid-protein-vp1-interacts-host-ribosomal-protein-sa
[2] http://www.indiaenvironmentportal.org.in/files/file/Foot-and-Mouth-Disease.pdf
[3] https://jvi.asm.org/content/94/3/e01350-19
[4] http://re.indiaenvironmentportal.org.in/category/author/lisa-j-henderson
[5] http://re.indiaenvironmentportal.org.in/category/author/lauren-b-reoma
[6] http://re.indiaenvironmentportal.org.in/category/author/joseph-kovacs-et-al
[7] http://re.indiaenvironmentportal.org.in/category/journal/journal-virology
[8] http://re.indiaenvironmentportal.org.in/category/thesaurus/foot-and-mouth-disease-hfmd
[9] http://re.indiaenvironmentportal.org.in/category/thesaurus/viral-diseases
[10] http://re.indiaenvironmentportal.org.in/category/thesaurus/livestock
[11] http://re.indiaenvironmentportal.org.in/category/thesaurus/animal-diseases