TRPV4-mediated calcium influx into human bronchial epithelia upon exposure to diesel exhaust particles

Human respiratory epithelia function in airway mucociliary clearance and barrier function and have recently been implicated in sensory functions. The authors investigated a link between chronic obstructive pulmonary disease (COPD) pathogenesis and molecular mechanisms underlying Ca2+ influx into human airway epithelia elicited by diesel exhaust particles (DEP).