Feature Article

Chikungunya virus is a mosquito-borne alphavirus which causes an acute febrile illness associated with polyarthralgia. Beginning in August 2013, clinicians from the Yap State Department of Health in the Federated States of Micronesia (FSM) identified an unusual cluster of illness which was subsequently confirmed to be chikungunya virus disease. Chikungunya virus disease previously had not been recognized in FSM.

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We summarize reasons for mandating independent monitoring of greenhouse gas emission reduction projects. In support of our policy recommendations, we describe a case study of a program designed to earn carbon credits by distributing almost one million drinking water filters in rural Kenya to avert the use of fuel for boiling water. We compare results from an assessment conducted by our research team in the program area among households with pregnant women or caregivers in rural villages with low piped water access with the reported program monitoring data and discuss the implications.

In Africa, a combination of better medicines and the widespread use of insecticides to kill mosquitoes has led to the decline in malaria cases and deaths. Millions of people in places like Dano are living longer, healthier lives because of this public health campaign. They are also more prosperous when they are malaria free, because the disease keeps kids home from school, prevents adults from working, and forces poor families to spend money on health care.

The 2014–15 Ebola virus disease (EVD) epidemic strained health systems in west Africa already overburdened with other diseases, including malaria. Because EVD and malaria can be difficult to distinguish clinically, and rapid testing was not available in many Ebola Treatment Units (ETUs), guidelines recommended empirical malaria treatment. Little is known, however, about the prevalence and characteristics of patients entering an ETU who were infected with malaria parasites, either alone or concurrently with Ebola virus.

Fighting wildfires in the United States costs billions of dollars annually. Public dialog and ongoing research have focused on increasing wildfire risk because of climate warming, overlooking the direct role that people play in igniting wildfires and increasing fire activity. Our analysis of two decades of government agency wildfire records highlights the fundamental role of human ignitions.

Zika is an emerging virus whose rapid spread is of great public health concern. Knowledge about transmission remains incomplete, especially concerning potential transmission in geographic areas in which it has not yet been introduced. To identify unknown vectors of Zika, we developed a data-driven model linking vector species and the Zika virus via vector-virus trait combinations that confer a propensity toward associations in an ecological network connecting flaviviruses and their mosquito vectors.

Current air traffic routing is motivated by minimizing economic costs, such as fuel use. In addition to the climate impact of CO2 emissions from this fuel use, aviation contributes to climate change through non-CO2 impacts, such as changes in atmospheric ozone and methane concentrations and formation of contrail-cirrus. These non-CO2 impacts depend significantly on where and when the aviation emissions occur. The climate impact of aviation could be reduced if flights were routed to avoid regions where emissions have the largest impact.

Among Canadian youth, 18% have tried cigarettes, with the range increasing from 3% among children in grade 6 to 36% among youth in grade 12. A person who starts smoking as a child or youth is less likely to quit later in life than someone who starts later. Factors such as age, sex, the influence of friends and family, and the broader social environment of school and community are linked to a youth’s decision to start smoking. Almost 90% of adult smokers first smoked tobacco by age 18.

Canada’s universal health care system does not include universal coverage of prescription drugs. We sought to estimate the effects of adding universal public coverage of an essential medicines list to existing public drug plans in Canada.

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Malaria parasites degrade substantial quantities of hemoglobin to release heme within a specialized digestive vacuole. Most of this heme is sequestered in an inert crystal. However, the concentration of bioavailable, labile heme in the parasite’s cytosol was unknown. We developed a biosensor to provide the first quantitative insights into labile heme concentrations in malaria parasites. We find that ∼1.6 µM labile cytosolic heme is maintained, including during a period coincident with intense hemoglobin degradation.