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The mobile colistin resistance gene mcr-1 has attracted global attention, as it heralds the breach of polymyxins, one of the last-resort antibiotics for the treatment of severe clinical infections caused by multidrug-resistant Gram-negative bacteria. To date, six slightly different variants of mcr-1, and a second mobile colistin resistance gene, mcr-2, have been reported or annotated in the GenBank database. Here, we characterized a third mobile colistin resistance gene, mcr-3.
On 23 March 2017, the British Medical Association, in partnership with the Sustainable Development Unit for the health sector in England, released Ethical procurement for health: workbook 2.0, 1 a guide and workbook for protecting labour rights in medical supply chains. This is an update to a document released 6 years earlier in response to evidence of abuse of worker rights at several factories manufacturing health-care products destined for global markets.
Evidence on the optimal time to initiation of complementary feeding in preterm infants is scarce. The researchers examined the effect of initiation of complementary feeding at 4 months versus 6 months of corrected age on weight for age at 12 months corrected age in preterm infants less than 34 weeks of gestation.
Egypt’s Nile delta, only ~1 m above mean sea level at the Mediterranean coast, is subject to uneven rates of submergence. This is a response to several factors leading to increasing land lowering (subsidence) of the northern delta and adjacent seafloor, plus an accelerating rise in eustatic (world) sea level in the Mediterranean. An average eustatic sea-level rise of ~3 mm/yr represents only ~26% to 45% of total relative sea-level rise measured along this margin.
Paying farmers for ecosystem services that they provide could be a novel way to achieve multiple goals of doubling the farm incomes, reduce rural–urban migration, reduce pressure on urban infrastructure, and at the same time, incentivise sustainable agrarian practices in India.
Emissions of aerosols and their precursors are declining due to policies enacted to protect human health, yet we currently lack a full understanding of the magnitude, spatiotemporal pattern, statistical significance, and physical mechanisms of precipitation responses to aerosol reductions. We quantify the global and regional precipitation responses to U.S. SO2 emission reductions using three fully coupled chemistry-climate models: Community Earth System Model version 1, Geophysical Fluid Dynamics Laboratory Coupled Model 3, and Goddard Institute for Space Studies ModelE2.
High antibiotic and antifungal concentrations in wastewater from anti-infective drug production may exert selection pressure for multidrug-resistant (MDR) pathogens. We investigated the environmental presence of active pharmaceutical ingredients and their association with MDR Gram-negative bacteria in Hyderabad, South India, a major production area for the global bulk drug market.
Increasing emission rate of carbon dioxide (CO2) and other greenhouse gases is the major driver of global temperature increase. Soil microbial respiration is accelerating the release of CO2 in the environment, but the mechanistic understanding of this process is still at its nascent stage. In this note, we discuss the importance of understanding the microbial responses to climate change and associated respiration process in the Indian Himalayan region.
he 2030 Agenda for Sustainable Development adopted by countries at the United Nations in 2015 sets forth a comprehensive vision of development with 17 Sustainable Development Goals (SDGs) and 169 targets across all aspects of society [1]. The 2030 Agenda document is ambitious and explicit about the need for integrated and sustained action across society to address complex challenges such as ending extreme poverty, reducing widening economic inequality, tackling climate change, and reducing and preventing conflict.
The molecular underpinnings of the dissociation of cognitive performance and neuropathological burden are poorly understood, and there are currently no known genetic or epigenetic determinants of the dissociation.
