Feature Article

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SARS-CoV-2 Infection in Children

As of March 10, 2020, the 2019 novel coronavirus (SARS-CoV-2) has been responsible for more than 110,000 infections and 4000 deaths worldwide, but data regarding the epidemiologic characteristics and clinical features of infected children are limited. A recent review of 72,314 cases by the Chinese Center for Disease Control and Prevention showed that less than 1% of the cases were in children younger than 10 years of age.

Publication Date: 
18/03/2020
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Covid-19: how doctors and healthcare systems are tackling coronavirus worldwide

As coronavirus continues to spread, doctors and healthcare systems are facing a multitude of challenges at all stages of the pandemic.

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Publication Date: 
18/03/2020
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A trial of Lopinavir–Ritonavir in adults hospitalized with severe Covid-19

Researchers conducted a randomized, controlled, open-label trial involving hospitalized adult patients with confirmed SARS-CoV-2 infection, which causes the respiratory illness Covid-19, and an oxygen saturation (Sao2) of 94% or less while they were breathing ambient air or a ratio of the partial pressure of oxygen (Pao2) to the fraction of inspired oxygen (Fio2) of less than 300 mm Hg.

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Publication Date: 
18/03/2020
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The proximal origin of SARS-CoV-2

Since the first reports of novel pneumonia (COVID-19) in Wuhan, Hubei province, China, there has been considerable discussion on the origin of the causative virus, SARS-CoV-23 (also referred to as HCoV-19).

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Publication Date: 
17/03/2020
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Aerosol and Surface Stability of SARS-CoV-2 as Compared with SARS-CoV-1

A novel human coronavirus that is now named severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (formerly called HCoV-19) emerged in Wuhan, China, in late 2019 and is now causing a pandemic. The researchers analyzed the aerosol and surface stability of SARS-CoV-2 and compared it with SARS-CoV-1, the most closely related human coronavirus.

Publication Date: 
17/03/2020
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Covid-19 and community mitigation strategies in a pandemic

The covid-19 pandemic that was declared on 11 March 2020 has affected countries on all continents. Reported case numbers are certainly underestimates given the shortages or unavailability of test kits in many countries, a virus with a basic reproductive value (R0) of 2.2, and evidence of viral shedding from asymptomatic infected people. (Editorial)

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Publication Date: 
17/03/2020
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The psychological impact of quarantine and how to reduce it: rapid review of the evidence

The December, 2019 coronavirus disease outbreak has seen many countries ask people who have potentially come into contact with the infection to isolate themselves at home or in a dedicated quarantine facility. Decisions on how to apply quarantine should be based on the best available evidence.

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Publication Date: 
14/03/2020
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Reinfection could not occur in SARS-CoV-2 infected rhesus macaques

An outbreak of the Corona Virus Disease 2019 (COVID-19), caused by the severe acute respiratory syndrome CoV-2 (SARS-CoV-2), began in Wuhan and spread globally. Recently, it has been reported that discharged patients in China and elsewhere were testing positive after recovering. However, it remains unclear whether the convalescing 24 patients have a risk of “relapse” or “reinfection”.

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Publication Date: 
13/03/2020
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Follow-up of a historic cohort of children treated for severe acute malnutrition between 1988 and 2007 in Eastern Democratic Republic of Congo

It is well documented that treatment for severe acute malnutrition (SAM) is effective. However, little is known about the long-term outcomes for children treated for SAM. We sought to trace former SAM patients 11 to 30 years after their discharge from hospital, and to describe their longer-term survival and their growth to adulthood.

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Publication Date: 
11/03/2020
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Conscientious vaccination exemptions in kindergarten to eighth-grade children across Texas schools from 2012 to 2018: A regression analysis

As conscientious vaccination exemption (CVE) percentages rise across the United States, so does the risk and occurrence of outbreaks of vaccine-preventable diseases such as measles. In the state of Texas, the median CVE percentage across school systems more than doubled between 2012 and 2018. During this period, the proportion of schools surpassing a CVE percentage of 3% rose from 2% to 6% for public schools, 20% to 26% for private schools, and 17% to 22% for charter schools.

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Publication Date: 
10/03/2020
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